Many institutions are focused on improving
processes and making them more efficient
with the reality of decreased funding and tight
resource allocation. Evaluating IACUC processes can allow both members and staff to find
opportunities enhanced operations. Pre-review
is one way in which protocol review times can
be shortened since concerns are dealt with by
the PI prior to committee review. IACUC members can then focus on their other functions
such as policy development, compliance oversight, programmatic needs, continuing education, and promoting the best care of research
animals at their institution.
To view the additional reading for this article, go
Stacy Pritt, DVM, MS, MBA, CPIA, DACAW is
the Director of IACUC at the UT Southwestern
Medical Center. She has over 10 years’ experience working in contract laboratories, including
oversight of animal welfare and regulatory
standing as a cause of prolonged times for
To make IACUC protocols IACUC ready, the
following subjects can then start to be incorpo-
rated into a more expansive IACUC pre-review
program. The focus here is not just that the
items have been included and addressed in the
protocol but that the content of the protocol is
appropriate enough for IACUC review without
the need for modifications. These subjects can
• Identify and ensure justifications for excep-
tions to the Guide are in place and would
be appropriate for committee review.
• Identify and ensure justifications to institutional policies are appropriate.
• Identify and ensure justifications required
by the AWARs, Guide, USDA Animal Care
policies, and NIH OLAW guidance are in
place and would be appropriate for committee review.
• Ensure flexibility in procedural descriptions to help avoid non-compliance with
• Ensure that pain and/or distress levels ani-
mals experience are appropriately identified
(required by the USDA AWARs) as defined
by the institution.
• Ensure that the appropriate key words for
required literature searches have been used.
Through training and mentoring with
IACUC leadership, staff can recognize parts
of the protocol that will need modifications
prior to protocol review. Those parts can be
revised quickly and upon confirmation by
IACUC staff that all pre-review comments
have been addressed, the protocol can be
submitted for IACUC review. It is incumbent
upon those managing the IACUC protocol
review process that multiple pre-review processes, if present, are accomplished in an
efficient manner. For example, veterinary and
IACUC staff pre-reviews could be conducted
simultaneously so that PIs receive only one
request for revisions prior to the protocol
being submitted for committee review. In this
case, IACUC staff would need to guarantee
that all revisions made to pre-review comments are complete and that the protocol is
indeed IACUC ready.
ORAL GAVAGE, REFINED
GAVAGE TRAINING VIDEOS
Instech’s plastic feeding needles have flexible tubes
and soft tips to reduce trauma, and they’re disposable
to eliminate the hassle of cleaning.
Available in a range of sizes for mice, rats
and other rodents.