This article was reprinted from The
IACUC Handbook, Third Edition by Jerald
Silverman, Mark A. Suckow, and Sreekant
Murthy. Copyright 2014 Taylor & Francis
Group, LLC, ISBN 978-1-4665-5564-8.
Reprinted with permission.
pliant with the federal guidelines and requirements. The sections labeled “regulatory”
have been reviewed by staff at NIH Office of
Laboratory Animal Welfare (OLAW) and USDA
APHIS/Animal Care (AC) for consistency and
com pliance with the PHS Policy and the USDA
Animal Welfare Act Regulations (AWAR).
The best practices presented were developed by conscientious IACUCs and research
teams from academia, industry, the private
and public sectors, and institutions of various sizes. Answers to a series of operational,
policy, and management questions are first
addressed from the perspective of the applicable regulatory language, followed by opinions from knowledgeable and experienced
professionals in the field, and in some cases
ultimately followed by responses to informal
surveys on selected institutional policies and
Every effort has been made to apply correct interpretations within the context of the
specific issues being discussed. However, in
this highly nuanced field, readers are cautioned not to apply these interpretations out
of context or to extend them beyond their
intended meaning. Accordingly, such interpretations should not be seen as formulating
new federal regulations or policies. Readers
are therefore advised to refer to source documents and engage in direct consultations with
NIH/OLAW and APHIS/AC when in doubt.
In addition, professional standards and policies change and evolve over time as a result
of new discoveries and new regulations. In
light of this, the reader is also advised to
keep abreast of developments while using this
handbook for guidance.
The information provided in the sections
labeled “survey” gives an interesting view of
how the surveyed institutions address certain
issues, but a note of caution is advised here
as well. Some responses may appear to indi-
cate deviations from federal policy and regula-
tion. This is a result of several variables (e.g.,
type of institution, species involved, applica-
ble oversight) that affect applicability or lead
to differences in interpretation of the survey
question. In light of this, survey responses
should not be construed as noncompliance
with the regulations For the experienced
reader and novice alike, this book provides
a wealth of useful information and insight
into the collective experience and wisdom
of the numerous expert editors and authors.
Both NIH/OLAW and APHIS/AC commend
the authors and editors for their outstand-
ing efforts and for moving the biomedical
research community forward in its formula-
tion of best practices and commonly accepted
professional guidance in this complex arena.